Experimentelle Kardiologie

Archiv

 

Historisches

  • Gründungssitzung Oktober 1992 in Graz
  • Formale Gründung der AG am 9. 1. 1993 ÖKG in Gastein
  • Gründer und erste AG-Leiter: Prof. Gasser (Graz), Prof. Huber (Wien)
  • Mithilfe bei der Gründung: Prof. Kühn (Linz), Prof. Kaindl (Wien)
  • Erster Nucleus:
    Wien: Prof. Glogar, Prof. Weidinger, Prof. Stefenelli
    Graz: Prof. Gasser, Prof. Rigler, Dr. Grisold, Prof. Koidl
    Innsbruck: Prof. Puschendorf,  Prof. Lechleitner, Prof. Dienstl, Prof. Mühlberger

 

 

Veranstaltungen 2011

  • Weissensee 2011
    Cardiovascular Research Days 2011 (gemeinsame Organistaion mit der AG ATVB)
  • ÖKG-Jahrestagung, Salzburg 2011

 

Veranstaltungen 2010

  • Weissenseetagung Jänner 2010
    Thema: The Old and Multimorbid Patient, a Challenge for Scientists and Clinicians
  • ÖKG-Jahrestagung, Salzburg 2010

 

Veranstaltungen 2008-2009

  • Cardiovascular Research Days, Weissensee, 2008
  • ÖKG-Jahrestagung, Salzburg 2009
  • Heart Failure with preserved Ejection Fraction (HFpEF) Graz/Schloss Pichlarn, 22.-25.10.2009

 

 

Aktivitäten 

2010/2011

  1. Nucleusmitglied der Working Group „Thrombosis" der ESC (Prof. Wojta)

  2. Co-ordinator des Ludwig Boltzmann Clusters „Cardiovascular Research“ (Prof. Wojta)

  3. Mitglied des Ludwig Boltzmann Clusters „Cardiovascular Research“ (Prof. Gyöngyösi,   Doz. Podesser, Dr. Tretscher)

  4. Kooperation mit dem Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis   and Regeneration (Prof. Gyöngyösi)

  5. Vertretung in der Österreichische Herzstiftung (Prof. Gasser)

 

Forschungsprojekte

  • Graz:
  • EC- und ET-Coupling
  • Herzinsuffizienz
  • Arrhythmogenese
  • Metabolismus
  • Innsbruck:
  • Ischämie/Reperfusion
    - in vivo, Maus
    - biomarkers
  • Wien:
  • Vaskuläre Biologie
    - Angiogenese
    - Thrombose/Hämostase
  • Remodeling nach Myokardinfarkt
  • 20 Postdocs
  • 20 Doktoranden
  • 4-5 Technicians

 

Scientific Highlights

 

2011

 

Bruno K. Podesser: PRIZE Award 2011 vom BM für Wirschaft für die Entwicklung und Patentierung von neu entwickelten COS-Verbindungen gemeinsam mit Prof. Dr. T. Erker (Uni Wien, Inst. Für Med. Chemie)

Gabriela Pomper: für die Entwickung von COS-Substanzen die Silbermedaille der „Korean International Woman's Invention Association”

Rayyan Hemetsberger: Wilhelm-Auerswald-Preises für die beste Dissertation des Jahres 2010 in Österreich

 

Mariann Gyöngyösi: Best basic abstract ÖKG 2011

 

 

3. Förderungszusage/Grants

1. Genehmigung und Einrichtung eines Ludwig Boltzmann Instituts für Translationale Herzinsuffizienzforschung (Gründung mit 01.10.2011; Antragsteller gemeinsam mit Burkert Pieske).

2. Experimental ballon dilation of the peripheral arteries using drug-eluting balloon: safety and efficacy study (Eurocor GmbH, MUW)

3. Experimental coronary artery dilation using new drug-eluting balloons in (Hemoteq GmbH, MUW)

 

4. Core-Lab Facilities (basic research)

4.1. Graz Universität, Abt Kardiologie

Simult. confocal imaging and whole cell-patch clamping

Simult. ratiometric fluometry, cell shortening and patch-clamping

Mol. Biol. (Western Blot, IP, activity assays)

In vivo : pressure volume in pigs and rats, echocardiography (mouse,rat,pig), TAC banding (mouse), LAD banding (rats)

Human atrial and ventricular cardiomyocyte studies (bulk and perfusion-based isolation)

Muscle strip (trabeculae from human and pig atria and ventricle) : stretch and force measurements

 

4.2. Podesser-group

 

Physiologische Untersuchungen vom Kleintier (Maus) bis Großtier (Schwein) zum Thema Ischämie/Reperfusion

Ex vivo Untersuchungen am isolierten Herz vom Mausmodell bis zum Kaninchen

4.3. Gyöngyösi-group (MUW)

Large animal model of acute and chronic myocardial ischemia

Experimental ASD and PFO occlusion

Coronary and peripheral arteries balloon dilation or stenting in pigs

Gene expression profiling analysis

Histologic work of stented arteries (plastik embedding and staining)

In vitro measurements of vascular reactivity after use of different coronary devices

 

 

2010-2011

Österreichischer Kardiologenpreis:

  1. M. Lichtenauer et al, MUW: „Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodeling by increasing elastin expression in cardiac scar tissue after myocardial infarction” (Basic Res Cardiol, 2011)
  2. S. Demyanets et al, MUW:   „Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-g”(Basic Res Cardiol, 2011)

 

Best abstracts, Basic Science:

M. Gyöngyösi et al, Univ. Klinik Inn. Med. II. Kardiologie, Wien:„Increased matrix metalloproteinase 2 expression of infarcted myocardium attenuates homing of mesenchymal stem cells“

Hans und Blanca Moser Stiftung:

G. Goliasch, Abteilung für Kardiologie, Med. Uni. Wien„Markers of bone        metabolism in premature myocardial infarction (≤40 years of age)“

2008-2009

CA2+/Calmodulin-Dependent Protein Kinase II-Gamma and Protein Kinase D Overexpression Reinforce the Histone Deacetylase 5 Redistribution in Heart Failure

Jule Bossuyt, Kathryn Helmstadter, Xu Wu, Hugh Clements-Jewery, Robert S. Haworth, Metin Avkiran, Jody L. Martin, Steven M. Pogwid, Donald M. Bers. Circ Res. 2008; 102:695-7021.

TOP PUBLICATIONS

 

Sacherer M, Sedej S, Wakula P, Wallner M, Vos MA, Kockskaemper J, Stiegler P, Sereinigg M, von Lewinski D, Antoons G, Pieske BM, Heinzel FR. JTV519 (K201) Reduces Sarcoplasmic Reticulum Ca2+ Leak and Improves Diastolic Function in vitro in Ouabain-Induced Cellular Ca2+ Overload in Murine and Human Non-Failing Myocardium. Br J Pharmacol 2012. IN PRESS

Beretta M, Wölkart G, Schernthaner M, Griesberger M, Neubauer R, Schmidt K, Sacherer M, Heinzel FR, Kohlwein SD, Mayer B. Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2. Circ Res. 2012 Feb 3;110(3):385-93. Epub 2011 Dec 29.

Biesmans L, Macquaide N, Heinzel FR, Bito V, Smith GL, Sipido KR. Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS One. 2011;6(10):e25100

Heinzel FR, MacQuaide N, Biesmans L, Sipido K. Dyssynchrony of Ca2+ release from the sarcoplasmic reticulum as subcellular mechanism of cardiac contractile dysfunction. J Mol Cell Cardiol. 2011 Mar;50(3):390-400.

 

Podesser BK. Editorial. The old and multimorbid patient- a challenge in cardiac surgery and cardiology. Eur Surg 2011, 43/2:62.                                                                                               

 

Podesser BK. The ageing population- a challenge for cardiovascular surgery. Eur Surg 2011, 43/2:63-68.                                                                                   

 

Schmidt WM, Mitterer G, Podesser BK. Gene expression profiles characterizing the progression of heart failure in patients with aortic valve stenosis. Eur Surg 2011, 43/2:110-119.                                                                                   

 

Lichtenauer M, Mildner M, Hoetzenecker K, Zimmermann M, Podesser BK, Sipos W, Berenyi E, Dworschak M, Tschachler E, Gyongyosi M, Ankersmit HJ. Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study. Basic Res Cardiol 2011:106:1283–1297.                                   

 

Lichtenauer M, Mildner M, Baumgartner A, Hasun M, Werba G, Beer L, Altmann P, Roth G, Gyongyosi M, Podesser BK, Ankersmit HJ. Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction. Basic Res Cardiol DOI 10.1007/s00395-011-0173-0.

 

Dietl W, Trescher K, Hohensinner P, Nagel F, Ma Y, Wolfsberger M, Plasenzotti R, Hoffmann-Sommergruber K, Wojta J, Bauer M, Podesser BK. SiNiTang – A Traditional Chinese Herbal Remedy Improves Cardiac Function Post-MI. J Clinic Experiment Cardiol 2011: 5-9.

                                                           

Hasun M, Trescher K, Dietl W, Bauer M, Hallström S, Podesser BK. New HTK-N46B cardioplegia provides superior protection during ischemia/reperfusion in failing hearts. J Cardiothorac Surg 2012 accepted.

 

Liao R, Podesser BK, Lim CC.  The Langendorff and the Working Heart Model: Historical Perspective and New Methods in the ex vivo Murine Heart. Am J Physiology 2012 accepted.

 

Gyöngyösi M, Dib N. Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease. Nature Reviews Cardiology 2011;8:393-404.

 

Gyöngyösi M, Hemetsbrger R, Wolbank S, Pichler V, Kaun C, Posa A, Petrasi Z, Petnehazy Ö, Hofer-Warbinek R, de Martin R, Gruber F, Benedek I, Benedek T, Kovacs I, Benedek I jr, Plass CA, Charwat S, Maurer G. Delayed recovery of myocardial blood flow after intracoronary stem cell administration. Stem Cell Rev. 2011 Sep;7(3):616-23.

 

Hemetsberger R, Posa A, Farhan S, Hemetsberger H, Redwan B, Pavo N, Pavo IJ, Plass CA, Petnehazy O, Petrasi Z, Huber K, Glogar D, Maurer G, Gyöngyösi M*. Drug-eluting introducer sheath prevents local peripheral complications pre-clinical evaluation of nitric oxide-coated sheath. JACC Cardiovasc Interv. 2011 Jan;4(1):98-106. *corresponding author

 

van der Spoel TI, Jansen Of Lorkeers SJ, Agostoni P, van Belle E, Gyöngyösi M, Sluijter JP, Cramer MJ, Doevendans PA, Chamuleau SA. Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease. Cardiovasc Res 2011 91(4):649-58.

 

Kastrup J, Jørgensen E, Fuchs S, Nikol S, Bøtker HE, Gyöngyösi M, Glogar D, Kornowski R. A randomised, double-blind, placebo-controlled, multicentre study of the safety and efficacy of BIOBYPASS (AdGVVEGF121.10NH) gene therapy in patients with refractory advanced coronary artery disease: the NOVA trial. EuroIntervention. 2011 Feb;6(7):813-8.

 

Schwarzmaier-D'Assie A, Nyolczas N, Hemetsberger R, Strehblow C, Matiasek J, Farhan S, Petrasi Z, Huber K, Wojta J, Glogar D, Plass C, Gyöngyösi M, Karnik R. Comparison of short- and long-term results of drug-eluting vs. bare metal stenting in the porcine internal carotid artery. J Endovasc Ther. 2011 Aug;18(4):547-58.

 

Demyanets S, Konya V, Kastl SP, Kaun C, Rauscher S, Niessner A, Pentz R, Pfaffenberger S, Rychli K, Lemberger CE, de Martin R, Heinemann A, Huk I, Gröger M, Maurer G, Huber K, Wojta J.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2080-9.

 

B.K.Podesser and D. Chambers editors. New solutions for the heart- an update in advanced perioperative protection Springer Verlag 2011

 

Atherosklerose, Thrombose und vaskuläre Biologie

Archiv

 

Veranstaltungen 2011

 

Jänner 2011, Innsbruck, AT

Integrated Management of Acute and Chronic CAD, Innsbruck

gemeinsam mit der WG on Thrombosis der ESC

 

 

 

März 2011, Wien, AT

Update in Rhythmology

Part der antithrombotischen Therapie

 

Juni 2011, Salzburg, AT

Jahrestagung der ÖKG

Organisation von 2 Symposien

 

19. 11. 2011, Wien, AT

Antithrombotische Therapie bei Herz-Kreislauferkrankungen

Kardiologische Seminare Wilhelminenberg

 

 

20.11.– 21.11.2011, Solingen, DE 

Joint meeting with the WG on Coronary Revascularisation of the DKG

 

 

Veranstaltungen 2010

 

Jänner 2010, Weissensee, AT

Joint meeting with the WG on Experimental Cardiology and Cardiovascular Surgery

Co-organizer Johann Wojta

 

Juni 2010, ÖKG,Salzburg, AT

Organisation von 2 Symposien

 

Juni 2010, Bad Horn, CH

Writing group expert meeting

Perioperative Strategies in Patients on Antiplatelet Therapy

Publikation in Thromb Haemost 2010/11, Huber et al

 

Juli 2010, Wien, AT

Consensus/Expert-Meeting

High-sensitive Troponins in daily Routine

Karl Mulac, Kurt Huber

 

September 2010, Graz, AT

Joint meeting with the Austrian Society of Anaesthesiology

Perioperative Strategies in Patients under Antithrombotic Therapy

Kurt Huber, Helfried Metzler

 

September 2010, Wien, AT

ALPE ADRIA CARDIOLOGY-Meeting

2 symposia about "Antithrombotic Therapy", 1 symposium about vascular biology

Organization and co-organization by Kurt Huber and Johann Wojta

 

November 2010, Solingen, DE

Joint meeting with the WG on Coronary Revascularisation of the DKG

 

 

 

 

 

 

Veranstaltungen 2009

 

Coronary Reperfusion and Secondary Prevention, Oberlech, 21.-26.3.2009

 

Oktober 2009, Oslo, NO

EuroThrombosis Summit meeting

together with the WG on Thrombosis of the ESC

Co-organizers: Johann Wojta, Kurt Huber

 

November 2009, München, DE

PCI-Meeting

Co-organizer Kurt Huber (responsible for topics: antithrombotic therapy)

 

November 2009, Solingen, DE

Joint meeting with the WG on Coronary Revascularization of the DKG

H-M Hoffmeister, Kurt Huber

 

 

November 2009, Wien, AT

Antithrombotische Therapie bei Herzerkrankungen

Kurt Huber, Harald Darius

 

Veranstaltungen/Fortbildungen 2007

  • ÖKG-Sitzung bei der ÖKG-Tagung 2007
  • Coronary reperfusion and secondary prevention; Oberlech, 14.-19.4.2007
  • Kardiologisch-hämostaseologischer Workshop; Solingen, 11.-12.11.2007 (gemeinsam mit AG Thrombose der ÖKG)
  • Antithrombotische Therapie bei kardialen Erkrankungen; Wien, 27.11.2007

 

Scientific Highlights

 

Dr. Jolanta Siller-Matula

ESC-Pressekonferenz 29. August 2010, Stockholm

What's new in antiplatelet therapy?

 

Mitarbeit an Studien:

HORIZON S, RE-LY; TRITON TIMI-38 (PPI Substudy), APPRAISE-1, SEPIA ACS-1, ATLAS-2

präsentiert am AHA 2009

 

Publikationen

 

  • K. Huber et al.
    Perioperative Strategies in Patients on Antiplatelet Therapy
    Publikation in Thromb Haemost 2010/11
  • Niessner A, Shin MS, Pryshchep O, Goronzy JJ, Chaikof EL, Weyand CM. Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque.Circulation. 2007 Oct 30;116(18):2043-52.
  • Schillinger M, Sabeti S, Dick P, Amighi J, Mlekusch W, Schlager O, Loewe C, Cejna M, Lammer J, Minar E. Sustained benefit at 2 years of primary femoropopliteal stenting compared with balloon angioplasty with optional stenting.Circulation. 2007 May 29;115(21):2745-9.
  • Diehm N, Baumgartner I, Jaff M, Do DD, Minar E, Schmidli J, Diehm C, Biamino G, Vermassen F, Scheinert D, van Sambeek MR, Schillinger M. A call for uniform reporting standards in studies assessing endovascular treatment for chronic ischaemia of lower limb arteries.Eur Heart J. 2007 Apr;28(7):798-805.
  • Rega G, Kaun C, Demyanets S, Pfaffenberger S, Rychli K, Hohensinner PJ, Kastl SP, Speidl WS, Weiss TW, Breuss JM, Furnkranz A, Uhrin P, Zaujec J, Zilberfarb V, Frey M, Roehle R, Maurer G, Huber K, Wojta J. Vascular endothelial growth factor is induced by the inflammatory cytokines interleukin-6 and oncostatin m in human adipose tissue in vitro and in murine adipose tissue in vivo.Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1587-95.
  • Stühlinger MC, Conci E, Haubner BJ, Stocker EM, Schwaighofer J, Cooke JP, Tsao PS, Pachinger O, Metzler B. Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.Cardiovasc Res. 2007 Jul 15;75(2):417-25.
  • G. Christ, K. Huber, et al
    Positionspapier "Perioperative antithrombotische Strategien bei Patienten unter dualer Antiplättchentherapie (AG Interventionelle Kardiologie und AG ATVB) (2009)
  • Korte W, Cattaneo M, Chassot PG, Eichinger S, von Heymann C, Hofmann N, Rickli H, Spannagl M, Ziegler B, Verheugt F, Huber K. Peri-operative management of antiplatelet therapy in patients with coronary artery disease: joint position paper by members of the working group on Perioperative Haemostasis of the Society on Thrombosis and Haemostasis Research (GTH), the working group on Perioperative Coagulation of the Austrian Society for Anesthesiology, Resuscitation and Intensive Care and the Working Group Thrombosis of the European Society for Cardiology (ESC). Thromb Haemost. 2011 May;105(5):743-9
  • Steg PG, Huber K, Andreotti F, Arnesen H, Atar D, Badimon L, Bassand JP, De Caterina R, Eikelboom JA, Gulba D, Hamon M, Helft G, Fox KA, Kristensen SD, Rao SV, Verheugt FW, Widimsky P, Zeymer U, Collet JP. Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J. 2011 Aug;32(15):1854-64. 

 

Forschungsprojekte

  • Impact of glycemic control and insulin resistance on the rate of instent restenosis in diabetic patients after drug eluting stent implantation. (LBI-Cluster for Cardiovascular Research, KH)
  • Angiogenese im Fettgewebe: Eine Verbindung zwischen Adipositas und kardiovaskulären Erkrankungen? (LBI-Cluster for Cardiovascular Research, JW)
  • Angiogenesis and disease: Regulation of mediators of tissue repair and angiogenesis in human hearts (FWF Forschungsschwerpunkt NFN94, JW)
  • The role of progenitor-cells in atherosclerotic lesion formation and vascular repair: Modulation by angiogenic growth factors (ATVB, WS)
  • Angiogenesis and Inflammation in Adipose Tissue: A link between obesity and cardiovascular disease
  • Impact of Glycemic Control and Insulin Resistance in Patients with Stable and Unstable Coronary Artery Disease
  • New Biomarkers in Coronary Artery Disease and Heart Failure (Co-Peptin, Adrenomedullin, Cystatin C) 
  • Platelet Function Testing after Coronary Stent Implantation

Aktuelle Veranstaltungen

Herzkatheter Kurs


St. Georg Business Hotel

93051 Regensburg, Karl-Stieler-Straße 8

Deutschland

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Herzschrittmacher Curriculum 2017


Theoretischer Sachkunde-Kurs

18. bis 20. September 2017

Schloss Wilhelminenberg

1160 Wien, Savoyenstraße 2

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6th Advanced Interventional Masterclass Radialis


FFR-Workshop

20.9.2017

AimRADIAL Kongress

21. und 22.9.2017

Stuttgart, Deutschland

 

Harbiye Military Museum – İstanbul / Turkey

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Herzinsuffizienz 2017 - Dreiländertreffen


Herzinsuffizienz - Innovative Herzinsuffizienztherapie im klinischen Alltag

21. bis 23. September 2017

Thun, Schweiz

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48. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin


Leitlinien vs. Erfahrungsmedizin

21. bis 23. September 2017

Salzburg Congress

5020 Salzburg, Auerspergstraße 6

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